Endocrine Abstracts

Introduction: Fahr’s syndrome in characterized by bilateral calcifications in basal ganglia, dentate nucleus and semioval center. Its clinical manifestations are a rigid hypokinetic syndrome, mood disorders and cognitive impairment. The most frequent aetiology of this syndrome is, together with idiopatic causes and congenital infections, calcium disorders, mainly primary hypoparathyroidism, accounting for up to 80% of all causes.Case report: A 57-ye...

Background: Depressive syndrome is a common psychiatric disorder in type 2 diabetic patients (T2DM), with negative outcomes in metabolic control and risk of developing cronic complications among these patients.Aims: i) To know the prevalence of depressive syndrome in a group of 113 T2DM seen consecutively in an endocrinologic outpatient clinic. ii) To analyze if there are any sociodemographic, clinical or biochemical differences between T2DM with positiv...

Introduction: Bone metastases (BM) are rare in differentiated thyroid cancer (DTC). They determine the quality of life and survival of these patients. Our objective was to evaluate the characteristics, survival and prognostic factors of a cohort of patients with BM from CDT.Methods: Retrospective descriptive study. Patients with BM from DTC diagnosed between 1980-2021 were included. Qualitative variables are shown as n(%); quantitative variables as media...

Background: The indication of ablation with I131 in low-risk DTC is controversial. The exact dose needed for thyroid remnant ablation is still a matter of debate in low-risk DTC patients. However, low dose has been found to be equally effective as high dose in terms of recurrence rate in recent studies. Taking this into account the current trend is to administer lower doses, although some studies describe a higher rate of retreatment.Aims: 1. To examine ...

Background: Autonomic hyperfunctioning thyroid nodules account for approximately 5% to 10% of all thyroid nodules. Compared with non-toxic nodules, hot nodules are traditionally believed to have an exceptionally low malignancy rate, and this has led to recommendations not to perform fine-needle aspiration (FNA) on these lesions, regardless of their size. However, recent studies have questioned the presumed low risk of malignancy in hot nodules, suggesting that the incidence of...

Purpose: To establish the safety and efficacy of multikinase inhibitors (MKIs) treatment in real life.Methods: This retrospective observational descriptive study included patients with advanced differentiated thyroid cancer in treatment with MKIs as first and second line treatment. From November 2011 to May 2022. Clinical variables, efficacy and adverse events (AE) were collected. Variables are expressed as median and interquartile range.<p class="ab...

Introduction: DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome is a severe multiorgan drug reaction, often associated with the development of autoimmune diseases. Pathogenically it has been related to the reactivation or the primary infection of different herpes virus.Clinical case: A 33-year-old woman with a history of residual epilepsy, after resection of a cerebellar pleomorphic xantoastrocytoma, started treatment with Levetirace...

Background: There is an increasingly aware of strong associations between obesity and attention-deficit/hyperactivity disorder (ADHD), with high rates of ADHD (26–61%) in patients seeking weight loss. Psychological evaluation is mandatory in patients presenting for bariatric surgery (BS), although it is focused on eating disorders and depression, with data lacking on ADHD. ADHD could increase the risk for less successful results after surgery because of noncompliance with...

Objective: To describe the characteristics, survival and prognostic factors of a cohort of patients with bone metastases (BM) of differentiated thyroid carcinoma (DTC).Methods: Multicenter retrospective observational study. Patients diagnosed with DTC and BM between 1980-2021 were included. A Cox regression was performed to study prognostic factors for 5- and 10-year survival. Kaplan-Meier and log-rank tests were performed for survival analysis and compa...